Directional constraint of endpoint force emerges from hindlimb anatomy

Directional constraint of endpoint force emerges from hindlimb anatomy.

Postural control requires the coordination of force production at the limb endpoints to apply an appropriate force to the body. Subjected to horizontal plane perturbations, quadruped limbs stereotypically produce force constrained along a line that passes near the center of mass. This phenomenon, referred to as the force constraint strategy, may reflect mechanical constraints on the limb or bod...

Collective cell durotaxis emerges from long-range intercellular force transmission.

The ability of cells to follow gradients of extracellular matrix stiffness-durotaxis-has been implicated in development, fibrosis, and cancer. Here, we found multicellular clusters that exhibited durotaxis even if isolated constituent cells did not. This emergent mode of directed collective cell migration applied to a variety of epithelial cell types, required the action of myosin motors, and o...

Extraction of individual muscle mechanical action from endpoint force.

Most motor tasks require the simultaneous coordination of multiple muscles. That coordination is poorly understood in part because there is no noninvasive means of isolating a single muscle's contribution to the resultant endpoint force. The contribution of a single motor unit to isometric tasks can, however, be characterized using the spike-triggered averaging (STA) technique, applied to a sin...

Inter-joint coupling effects on muscle contributions to endpoint force and acceleration in a musculoskeletal model of the cat hindlimb.

The biomechanical principles underlying the organization of muscle activation patterns during standing balance are poorly understood. The goal of this study was to understand the influence of biomechanical inter-joint coupling on endpoint forces and accelerations induced by the activation of individual muscles during postural tasks. We calculated induced endpoint forces and accelerations of 31 ...

Modeling robot flexibility for endpoint force control